Perpustakaan Terpadu

Abstract
Current prevention strategies suggest that immunization is still the best option against measles and can manipulate the biologic characters of these viruses. However, immunization is often ineffective in a number of children because of the biological trait of different ages. To a significant extent, this phenomenon is caused by internal and external factors that influence children’s immunity. One of the external factors in this regard is the benzo[a]pyrene pollutant, both directly and indirectly. Accumulated benzo[a]pyrene can infiltrate deoxyribonucleic acid (DNA) to form benzo[a]pyrene and AhR bonds (Aryl Hydrocarbon Receptor). Such bonds affect the differentiation of immune cells, resulting in immunosuppressive activity. This study aims to analyze the bioactivity of benzo[a]pyrene with respect to the expression of CD4+CD62L+, CD8+CD62L+, and CD4+IFNŸ in a measles paramyxovirus-vaccinated mouse. Approximately 20 mg/kg BW of benzo[a]pyrene was injected using an intramuscular approach twice per week for one month. Furthermore, flow cytometric analysis was performed to determine immune cell expression. The results showed that mice under-vaccination and benzo[a]pyrene treatment suppress the expression of CD4+CD62L+ naïve T cells, increases the expression of CD8+CD62L+ naïve T cells, and reduces the expression of CD4+IFNŸ. Controlling internal and external factors enhanced the effectiveness of measles immunization in children.

ABSTRACT
Background: Infodemics, phenomena of tsunami information, get along with wirh pandemic
Covid-19. In order to stop the spread of Covid-19 currently students stay at home and exposed
by internet and social media where all the information seems to be difficult to differentiate
between fact or hoax of Covid-19. The purpose of this study was to describe knowledge, attitude
and behaviour toward hoax covid-19 among polytechnic of health students.
Methods: This research was using quantitative design study. This descriptive online survey was
conducted in a week. There were about 750 respondents of the study. The sampling method was
stratified random sampling. Using snowballing technique, we spread the questionnaire online.
Results: 57% of respondents not always updating their knowledge about Covid-19. 72% of the
respondents admit that sometime they can’t differentiate between fact and hoax about Covid-19.
100% of respondents understand the definition of hoax. 74% of respondents found hoax news of
Covid-19
in
social
media.
However,
78,9%
of
respondents
having
high
knowledge
to
differentiate between fact and news of Covid-19 news.
About 41% of respondents choose to
clarify the fact if they receive any news about Covid-19. 84% of respondents admit that they
never forward any hoax news of Covid-19. Almost 92,9% of respondents do clarify the news and
20,4% of them choose to do check and recheck using social media when receive news about
Covid-19.
Conclusion: time allocation to use internet and media social is quite high among health students
it’s getting higher during pandemic Covid-19 because they have to stay at home. Ability to
differentiate between fact and hoax news is important while they were exposed by internet.
Media literacy is one of things that will help them to increase that ability. By having adequate
knowledge and attitude about media literacy and substantion of covid-19 we hope that all
students have an adequate prevention.